The Supercritical Fluids Area represents the core of the technical and scientific knowledge of the research group. The group has carried out research activity on supercritical fluids, mainly carbon dioxide and supercritical water, since 1994, and is currently one of the most recognized groups in this field worldwide.

The group’s strategy is based on process engineering based on a study of the fundamentals of the processes: physical-chemical properties, thermodynamics, mechanisms, mathematical modeling, to reach a product engineering oriented to specific applications.

The experience accumulated by the group in its three decades of activity in this field covers extraction and fractionation processes, precipitation processes and formulation of materials, reaction processes and products with applications in the food, pharmaceutical, energy or materials industries.

Ángel Martín

Chem. Eng. Full Professor

Soraya Rodríguez

Chem. Eng. Associate Professor

Esther Alonso

Chem. Eng. Full Professor

María José Cocero

Chem. Eng. Full Professor

Fields of activity

  • Determination of solubility and thermodynamic equilibrium data in supercritical fluids.
  • Extraction of natural and pharmaceutical actives by means of supercritical carbon dioxide.
  • Recrystallization of natural and pharmaceutical actives by means of supercritical carbon dioxide: SAS, PGSS, PGSS-drying processes.
  • Encapsulation of natural and pharmaceutical actives by supercritical fluid processes: encapsulation by SAS, PGSS, PGSS-drying, supercritical extraction of emulsions, precipitation from pressurized emulsions.
  • Development of formulations with improved properties: release rate control, solubility enhancement, release modulated by temperature or pH changes.
  • Manufacture of mesoporous aerogels by drying with supercritical fluids: silica, alginate, cellulose or carbon aerogels.
  • Reaction processes in carbon dioxide or supercritical water.

Research services offer

  • Determination of phase equilibrium data at high pressure and temperature (up to 500 bar, 300ºC) or with supercritical fluids.
  • Extraction of active compounds with supercritical carbon dioxide.
  • Recrystallization and formulation of active compounds using pressurized fluid processes.
    Preparation of aerogels.
  • Reaction experiments at high pressure and temperature or with supercritical fluids.
  • Modeling of extraction, precipitation and reaction processes.

Consulting services offer

  • Procesos de extracción y formulación a alta presión y temperatura.


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Grupo de Tecnologías a Presión Instituto de Bioeconomía
Calle Dr. Mergelina
47011 Valladolid (España)